Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging.
Identifieur interne : 000028 ( Main/Exploration ); précédent : 000027; suivant : 000029Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging.
Auteurs : Michael A. Paltsev [Russie] ; Victoria O. Polyakova [Russie] ; Igor M. Kvetnoy [Russie] ; George Anderson [Royaume-Uni] ; Tatiana V. Kvetnaia [Russie] ; Natalia S. Linkova [Russie] ; Ekaterina M. Paltseva [Russie] ; Rosa Rubino [Italie] ; Salvatore De Cosmo [Italie] ; Angelo De Cata [Italie] ; Gianluigi Mazzoccoli [Italie]Source :
- Oncotarget ; 2016.
Abstract
Deficits in neuroendocrine-immune system functioning, including alterations in pineal and thymic glands, contribute to aging-associated diseases. This study looks at ageing-associated alterations in pineal and thymic gland functioning evaluating common signaling molecules present in both human and animal pinealocytes and thymocytes: endocrine cell markers (melatonin, serotonin, pCREB, AANAT, CGRP, VIP, chromogranin А); cell renovation markers (p53, AIF, Ki67), matrix metalloproteinases (MMP2, MMP9) and lymphocytes markers (CD4, CD5, CD8, CD20). Pineal melatonin is decreased, as is one of the melatonin pathway synthesis enzymes in the thymic gland. A further similarity is the increased MMPs levels evident over age in both glands. Significant differences are evident in cell renovation processes, which deteriorate more quickly in the aged thymus versus the pineal gland. Decreases in the number of pineal B-cells and thymic T-cells were also observed over aging. Collected data indicate that cellular involution of the pineal gland and thymus show many commonalities, but also significant changes in aging-associated proteins. It is proposed that such ageing-associated alterations in these two glands provide novel pharmaceutical targets for the wide array of medical conditions that are more likely to emerge over the course of ageing.
DOI: 10.18632/oncotarget.7863
PubMed: 26943046
Affiliations:
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Paltsev</name><affiliation wicri:level="1"><nlm:affiliation>Russian Academy of Science, Moscow, Russian Federation, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Russian Academy of Science, Moscow, Russian Federation</wicri:regionArea><wicri:noRegion>Russian Federation</wicri:noRegion></affiliation></author><author><name sortKey="Polyakova, Victoria O" sort="Polyakova, Victoria O" uniqKey="Polyakova V" first="Victoria O" last="Polyakova">Victoria O. Polyakova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation</wicri:regionArea><wicri:noRegion>Russian Federation</wicri:noRegion></affiliation></author><author><name sortKey="Kvetnoy, Igor M" sort="Kvetnoy, Igor M" uniqKey="Kvetnoy I" first="Igor M" last="Kvetnoy">Igor M. Kvetnoy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation</wicri:regionArea><wicri:noRegion>Russian Federation</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name><affiliation wicri:level="1"><nlm:affiliation>CRC Scotland and London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Scotland and London</wicri:regionArea></affiliation></author><author><name sortKey="Kvetnaia, Tatiana V" sort="Kvetnaia, Tatiana V" uniqKey="Kvetnaia T" first="Tatiana V" last="Kvetnaia">Tatiana V. Kvetnaia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation</wicri:regionArea><wicri:noRegion>Russian Federation</wicri:noRegion></affiliation></author><author><name sortKey="Linkova, Natalia S" sort="Linkova, Natalia S" uniqKey="Linkova N" first="Natalia S" last="Linkova">Natalia S. Linkova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation</wicri:regionArea><wicri:noRegion>Russian Federation</wicri:noRegion></affiliation></author><author><name sortKey="Paltseva, Ekaterina M" sort="Paltseva, Ekaterina M" uniqKey="Paltseva E" first="Ekaterina M" last="Paltseva">Ekaterina M. Paltseva</name><affiliation wicri:level="1"><nlm:affiliation>Division of Immuhistochemistry, B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Division of Immuhistochemistry, B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation</wicri:regionArea><wicri:noRegion>Russian Federation</wicri:noRegion></affiliation></author><author><name sortKey="Rubino, Rosa" sort="Rubino, Rosa" uniqKey="Rubino R" first="Rosa" last="Rubino">Rosa Rubino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author><author><name sortKey="De Cosmo, Salvatore" sort="De Cosmo, Salvatore" uniqKey="De Cosmo S" first="Salvatore" last="De Cosmo">Salvatore De Cosmo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author><author><name sortKey="De Cata, Angelo" sort="De Cata, Angelo" uniqKey="De Cata A" first="Angelo" last="De Cata">Angelo De Cata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author><author><name sortKey="Mazzoccoli, Gianluigi" sort="Mazzoccoli, Gianluigi" uniqKey="Mazzoccoli G" first="Gianluigi" last="Mazzoccoli">Gianluigi Mazzoccoli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="e-ISSN">1949-2553</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deficits in neuroendocrine-immune system functioning, including alterations in pineal and thymic glands, contribute to aging-associated diseases. This study looks at ageing-associated alterations in pineal and thymic gland functioning evaluating common signaling molecules present in both human and animal pinealocytes and thymocytes: endocrine cell markers (melatonin, serotonin, pCREB, AANAT, CGRP, VIP, chromogranin А); cell renovation markers (p53, AIF, Ki67), matrix metalloproteinases (MMP2, MMP9) and lymphocytes markers (CD4, CD5, CD8, CD20). Pineal melatonin is decreased, as is one of the melatonin pathway synthesis enzymes in the thymic gland. A further similarity is the increased MMPs levels evident over age in both glands. Significant differences are evident in cell renovation processes, which deteriorate more quickly in the aged thymus versus the pineal gland. Decreases in the number of pineal B-cells and thymic T-cells were also observed over aging. Collected data indicate that cellular involution of the pineal gland and thymus show many commonalities, but also significant changes in aging-associated proteins. It is proposed that such ageing-associated alterations in these two glands provide novel pharmaceutical targets for the wide array of medical conditions that are more likely to emerge over the course of ageing.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Royaume-Uni</li><li>Russie</li></country></list><tree><country name="Russie"><noRegion><name sortKey="Paltsev, Michael A" sort="Paltsev, Michael A" uniqKey="Paltsev M" first="Michael A" last="Paltsev">Michael A. Paltsev</name></noRegion><name sortKey="Kvetnaia, Tatiana V" sort="Kvetnaia, Tatiana V" uniqKey="Kvetnaia T" first="Tatiana V" last="Kvetnaia">Tatiana V. Kvetnaia</name><name sortKey="Kvetnoy, Igor M" sort="Kvetnoy, Igor M" uniqKey="Kvetnoy I" first="Igor M" last="Kvetnoy">Igor M. Kvetnoy</name><name sortKey="Linkova, Natalia S" sort="Linkova, Natalia S" uniqKey="Linkova N" first="Natalia S" last="Linkova">Natalia S. Linkova</name><name sortKey="Paltseva, Ekaterina M" sort="Paltseva, Ekaterina M" uniqKey="Paltseva E" first="Ekaterina M" last="Paltseva">Ekaterina M. Paltseva</name><name sortKey="Polyakova, Victoria O" sort="Polyakova, Victoria O" uniqKey="Polyakova V" first="Victoria O" last="Polyakova">Victoria O. Polyakova</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Rubino, Rosa" sort="Rubino, Rosa" uniqKey="Rubino R" first="Rosa" last="Rubino">Rosa Rubino</name></noRegion><name sortKey="De Cata, Angelo" sort="De Cata, Angelo" uniqKey="De Cata A" first="Angelo" last="De Cata">Angelo De Cata</name><name sortKey="De Cosmo, Salvatore" sort="De Cosmo, Salvatore" uniqKey="De Cosmo S" first="Salvatore" last="De Cosmo">Salvatore De Cosmo</name><name sortKey="Mazzoccoli, Gianluigi" sort="Mazzoccoli, Gianluigi" uniqKey="Mazzoccoli G" first="Gianluigi" last="Mazzoccoli">Gianluigi Mazzoccoli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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